Iron deficiency anemia symptoms and causes mayo clinic. Pdf oral manifestations and blood profile in patients. Oral manifestations of blood disorders linkedin slideshare. The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities.
The clinician judges the state of the vascular system of his patient by noting the condition of the peripheral capillaries as it is manifested in the color of the lips and nails and the general appearance of the skin. Distribution of oral manifestation of anemia no oral manifestation. Pdf orofacial manifestations associated with anemia. Comparable items are sufficiently sinus and jaw bone patterns can be identified only on radiographs. Diagnosis of iron deficiency anemia through oral manifestation. Patients with this type of anemia must visit the dentist consistently for oral cancer screenings as well as regular dental care. Oral manifestations of blood disorders arsalan wahid malik. As discussed here, oral manifestations can be the presenting symptom for many systemic diseases, and thus a careful medical and social history is critical to. Angular stomatitis painful fissures at the corners of the mouth and cheilosis dry scaling of the. Pdf oral manifestations in patients with aplastic anemia.
The oral manifestations and mean red blood cell rbc count, corpuscular cell volume, rbc distribution width, mentzer index, and green and king index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin b12, folic acid, and homocysteine in 75 ida patients and in 150 age and sexmatched healthy controls were measured and compared. Introduce the systemic classification of anemia on the basis of morphology and red blood cell production. Currently, the only potential cure for hematological disorders is hematopoietic stem cell transplantation hsct. Hemolytic anemia is a condition when there is a decreased number of erythrocyte in the circulation due to premature destruction. Fanconi anemia fa is a genetic disease that is characterized by several congenital abnormalities and progressive bone marrow failure and is associated with an increased susceptibility to malignant disorders. The presence of oral signs and symptoms, including glossitis, angular cheilitis, recurrent oral ulcer, oral candidiasis, diffuse erythematous mucositis and pale oral mucosa offer the dentist an opportunity to participate in the diagnosis of this. Pale oral mucosa loss of papillae from tongue angular chelitis oral infection aphthae burning or sore tongue. They may be the direct result of disease pathology, secondary infiltrative processes, or treatmentrelated adverse effects.
Oral manifestations and blood profile in patients with. It is important to remember that biofilm is the etiologic agent of gingivitis and gingival bleeding is one of the main clinical signs of this inflammation. Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Oral manifestations of sickle cell disease article pdf available in british dental journal official journal of the british dental association. Titilope a adeyemo, wasiu l adeyemo, adewumi adediran, abd jaleel a akinbami, alani s akanmu departments of haematology and blood transfusion and oral and maxillofacial surgery, college of medicine, university of lagos, nigeria. Diminished salivary flow is a common oral feature of diabetes and may or may not include symptoms of a burning sensation in the mouth or tongue and concomitant enlargement of the parotid salivary glands. Fanconi anemia, according to the nhlbi, is a genetic condition that increases the risk of oral cancer. Sep 21, 2011 pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Brennan mt1, sankar v, baccaglini l, pillemer sr, kingman a, nunez o, young ns, atkinson jc. Gaddey, md on examination, the oral cavity may exhibit manifestations of underlying systemic disease and serve as an.
He determines the force and power of the circulation by the pulse, and by the. White plaques seem to have a directly proportional relationship with posthematopoietic stem cell transplantation periods. Anemia is often selfinduced, and can therefore be prevented through a healthy, wellrounded diet. Oral findings of anemia may include mucosal pallor, atrophic glossitis, and candidiasis. Oral signs of leukemia and dental management literature.
Oral manifestations of nutritional deficiencies include nonspecific signs and symptoms that involve the mucous membrane, the teeth and the periodontal tissues, salivary glands and peri oral skin. C 4, 11, 14 all adult men and postmenopausal women with iron deficiency anemia should be screened for gastrointestinal malignancy. Request pdf oral manifestations of anaemia anaemia is a disease characterized by a decreased concentration of haemoglobin in the blood below the estimated range given by gender and age. Iron deficiency anemia ida is the most common type of anemia. Anemia caused due to iron deficiency which is caused due to blood loss has many oral signs and symptoms and it is important to a dentist to identify these and act accordingly. Modifications in dental treatment and consultation with the patients primary care physician are necessary when a thyroid disease is suspected. A plastic anemia aa is a rare blood dyscrasia in which peripheral blood pancytopenia results from reduced or absent blood cell production in the bone marrow, and normal hematopoietic tissue in the bone marrow has been replaced by fatty marrow. Oral manifestations in congenital hypoplastic anemia. Sep 28, 2000 the prevalence, risk factors and significance of oral manifestations in aplastic anemia have not been well characterized. Oral manifestations of anemia in hivaids patients without arv treatment wahyu hidayat et al.
Oral manifestations many oral manifestations are common to different type of anemia, but some may be more specific oral findings in patients with anemia usually relate to the underlying cause of the anemia. Iron deficiency anemia is a common type of anemia a condition in which blood lacks adequate healthy red blood cells. Describe the metabolic and physiologic responses to anemia, with emphasis on those that give rise to the clinical findings c. Comprehensive oral rehabilitation of a patient with. Mucosal pallor, jaundice, and paresthesia may appear as the oral manifestations of hemolytic anemia. Disorders of rbc irondeficiency anemia megaloblastic anemia pernicious anemia aplastic anemia haemolytic anemia sicklecell anemia. Associations between oral manifestations dental management were also comment. Background purpose iron deficiency anemia ida is the most common type of anemia. Brennan mt, sankar v, baccaglini l, pillemer sr, kingman a, nunez o et al. Sue seale, dds, msd abstract congenital hypoplastic anemia is a rare disease characterized by a normochromic, normocytic anemia, a deficiency of erythroblasts in the marrow, and normal leukocyte and platelet counts. Prevalence and oral manifestations of iron deficiency anemia. A 48yearold man came to oral medicine clinic with complaint of discomfort. A 48yearold man came to oral medicine clinic with complaint of discomfort and spontaneous bleeding from a bump on the left of his tongue.
Oral symptoms and signs may include atrophic glossitis ag, generalized oral mucosal atrophy, and tenderness or burning sensation of oral mucosa. Pdf oral manifestations and blood profile in patients with iron. Oral manifestations of systemic diseases are common and diverse. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Oral manifestations of nutritional deficiencies include nonspecific signs and symptoms that involve the mucous membrane, the teeth and the periodontal tissues, salivary glands and perioral skin. Oral signs and symptoms of anemia due to iron deficiency. Case report a 68yearold female patient presented to the department of oral medicine with a chief complaint of. Therefore, thrombocytopenia acts as a modifying agent of the. Sickle cell anemia is a multisystem disease that can affect the oral region. Pdf backgroundpurpose iron deficiency anemia ida is the most common type of anemia. Plummervinson syndrome pvs is a triad of microcytic hypochromic anemia, atrophic glossitis, and esophageal webs or strictures.
Oral manifestations and blood profile in patients with iron deficiency. Nutrition and oral mucosal diseases danielle marie thomas, baa, ginat w. To evaluate and describe clinical, oral and radiographic manifestations of patients with fa. Jun 17, 2015 clinical features and oral manifestations of iron deficiency anemia often asymptomatic, may have nonspecific symptoms such as weakness and fatigue in severe cases may see angular cheilitis, pallor of oral tissue, and an erythematous, smooth, painful tongue 617201585. C 6, 7 all pregnant women should be screened for iron deficiency anemia. A case report helder antonio rebelo pontes, dds, msc, phd. The effects of diabetes on oral health have been studied extensively. The prevalence, risk factors and significance of oral manifestations in aplastic anemia have not been well characterized. Additional oral manifestations of lupus erythematosus may include honeycomb plaques silvery white, scarred plaques. Pdf oral manifestations of hematological disorders. Mar 09, 2015 oral manifestations of blood disorders arsalan wahid malik. Oral manifestations of aplastic anemia full text view. Oral manifestations of iron deficiency anaemia include angular cheilitis and atrophic glossitis or generalized oral mucosal atrophy neville et al. Oral manifestations of vitamin deficiencies pdf free pdf.
Pdf oral cavity is the window to the body and is often the area where systemic disease first presents itself. Oral manifestations of anemia in hivaids patients without. Oral manifestations in patients with aplastic anemia. Hyperkeratotic and lichenoid lesions were the manifestations most frequent observed.
Case report a 68yearold female patient presented to the department of oral medicine with a chief complaint of mobility of the lower left teeth for 3 months. Abnormal laboratory findings test requested patients values normal values lactate dehydrogenase 339 ul 60230 ul total bilirubin 3. However, 1 of the most common complications after hsct is the. A case history describes a patient with multiple oral problems after a sickle cell crisis. Pale oral mucosa loss of papillae from tongue angular. Oral manifestations in acute leukemia as the first sign. This sample of patients with fanconi anemia presented a high prevalence of oral chronic graftversushost disease. A quantitative analysis of clinical manifestations, oral lesions and panoramic radiographs was performed in 33 patients. Table 1 shows the prevalence rates of these and other oral manifestations in. Aug 04, 2014 plummervinson syndrome pvs is a triad of microcytic hypochromic anemia, atrophic glossitis, and esophageal webs or strictures. Orofacial manifestations of hematological disorders. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of. Clinical features and oral manifestations of iron deficiency anemia often asymptomatic, may have nonspecific symptoms such as weakness and fatigue in severe cases may see angular cheilitis, pallor of oral tissue, and an erythematous, smooth, painful tongue 617201585.
Iron deficiency anemia is the most common type of anemia which affects approximately 30% of the worlds population. Without enough iron, your body cant produce enough of a substance in red blood cells that enables. Hb description from the patients no name n averages median intervals 1 hb 40 10. With a decrease in the hemoglobin content of the blood the output of the heart is increased. Diagnosis and management of pernicious anemia springerlink.
Oral ulceration may be found in patients with lupus erythematosus, pemphi. Serological markers suggesting the presence of oxyntic mucosa damage are. As the name implies, iron deficiency anemia is due to insufficient iron. Symptoms resulting from anemia predominates the clinical picture, apart from the additional features such as glossitis, angular cheilitis, and dysphagia. Profound circulatory changes occur in both primary and secondary anemia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
A 54yearold woman applied to medical university, faculty of dentistry, department of oral and maxillofacial surgery, with the chief complaint of severe gingival. Melanin pigmentation on oral mucosa, traumatic lesions, gingival bleeding, dental biofilm and gingival alterations are the main oral manifestations of aplastic anemia patients. Oral manifestations in congenital hypoplastic anemia diamondblackfan anemia. Measurement of the serum ferritin level is the most accurate test to diagnose iron deficiency anemia.
540 161 360 580 602 1238 1470 795 1173 857 1344 584 453 883 685 1143 528 22 134 229 1114 534 590 746 363 3 252 633 130 574 1090 680 1434 901