Oral manifestations and blood profile in patients with. Measurement of the serum ferritin level is the most accurate test to diagnose iron deficiency anemia. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of. Diminished salivary flow is a common oral feature of diabetes and may or may not include symptoms of a burning sensation in the mouth or tongue and concomitant enlargement of the parotid salivary glands. The presence of oral signs and symptoms, including glossitis, angular cheilitis, recurrent oral ulcer, oral candidiasis, diffuse erythematous mucositis and pale oral mucosa offer the dentist an opportunity to participate in the diagnosis of this. To evaluate and describe clinical, oral and radiographic manifestations of patients with fa. Oral signs of leukemia and dental management literature. With a decrease in the hemoglobin content of the blood the output of the heart is increased. Iron deficiency anemia symptoms and causes mayo clinic. Mar 09, 2015 oral manifestations of blood disorders arsalan wahid malik. Diagnosis of iron deficiency anemia through oral manifestation. Oral manifestations and blood profile in patients with iron deficiency. Hb description from the patients no name n averages median intervals 1 hb 40 10. The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities.
He determines the force and power of the circulation by the pulse, and by the. Oral manifestations of vitamin deficiencies pdf free pdf. Comprehensive oral rehabilitation of a patient with. Pale oral mucosa loss of papillae from tongue angular. Modifications in dental treatment and consultation with the patients primary care physician are necessary when a thyroid disease is suspected.
Currently, the only potential cure for hematological disorders is hematopoietic stem cell transplantation hsct. Oral ulceration may be found in patients with lupus erythematosus, pemphi. Iron deficiency anemia ida is the most common type of anemia. Prevalence and oral manifestations of iron deficiency anemia. Disorders of rbc irondeficiency anemia megaloblastic anemia pernicious anemia aplastic anemia haemolytic anemia sicklecell anemia. Sep 28, 2000 the prevalence, risk factors and significance of oral manifestations in aplastic anemia have not been well characterized. Anemia caused due to iron deficiency which is caused due to blood loss has many oral signs and symptoms and it is important to a dentist to identify these and act accordingly. A case history describes a patient with multiple oral problems after a sickle cell crisis. Melanin pigmentation on oral mucosa, traumatic lesions, gingival bleeding, dental biofilm and gingival alterations are the main oral manifestations of aplastic anemia patients. Oral manifestations in congenital hypoplastic anemia diamondblackfan anemia. Sep 21, 2011 pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. A 48yearold man came to oral medicine clinic with complaint of discomfort and spontaneous bleeding from a bump on the left of his tongue. Orofacial manifestations of hematological disorders. Serological markers suggesting the presence of oxyntic mucosa damage are.
Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. The effects of diabetes on oral health have been studied extensively. Oral manifestations of aplastic anemia in children. Plummervinson syndrome pvs is a triad of microcytic hypochromic anemia, atrophic glossitis, and esophageal webs or strictures. Oral signs and symptoms of anemia due to iron deficiency. Clinical features and oral manifestations of iron deficiency anemia often asymptomatic, may have nonspecific symptoms such as weakness and fatigue in severe cases may see angular cheilitis, pallor of oral tissue, and an erythematous, smooth, painful tongue 617201585. Titilope a adeyemo, wasiu l adeyemo, adewumi adediran, abd jaleel a akinbami, alani s akanmu departments of haematology and blood transfusion and oral and maxillofacial surgery, college of medicine, university of lagos, nigeria.
Oral manifestations of nutritional deficiencies include nonspecific signs and symptoms that involve the mucous membrane, the teeth and the periodontal tissues, salivary glands and peri oral skin. Profound circulatory changes occur in both primary and secondary anemia. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Patients with this type of anemia must visit the dentist consistently for oral cancer screenings as well as regular dental care. A 48yearold man came to oral medicine clinic with complaint of discomfort. Brennan mt, sankar v, baccaglini l, pillemer sr, kingman a, nunez o et al.
Pdf orofacial manifestations associated with anemia. Case report a 68yearold female patient presented to the department of oral medicine with a chief complaint of. Abnormal laboratory findings test requested patients values normal values lactate dehydrogenase 339 ul 60230 ul total bilirubin 3. Oral manifestations in acute leukemia as the first sign. A case report helder antonio rebelo pontes, dds, msc, phd. Oral manifestations of systemic diseases are common and diverse. Fanconi anemia fa is a genetic disease that is characterized by several congenital abnormalities and progressive bone marrow failure and is associated with an increased susceptibility to malignant disorders. Iron deficiency anemia is a common type of anemia a condition in which blood lacks adequate healthy red blood cells. C 6, 7 all pregnant women should be screened for iron deficiency anemia. Aug 04, 2014 plummervinson syndrome pvs is a triad of microcytic hypochromic anemia, atrophic glossitis, and esophageal webs or strictures.
Kaidonis school of dentistry, the university of adelaide, adelaide, south australia, australia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. Oral findings of anemia may include mucosal pallor, atrophic glossitis, and candidiasis. Iron deficiency anemia is the most common type of anemia which affects approximately 30% of the worlds population. Oral manifestations of aplastic anemia full text view. Oral manifestations of iron deficiency anaemia include angular cheilitis and atrophic glossitis or generalized oral mucosal atrophy neville et al.
Oral manifestations of blood disorders linkedin slideshare. A 54yearold woman applied to medical university, faculty of dentistry, department of oral and maxillofacial surgery, with the chief complaint of severe gingival. The oral manifestations of painful atrophy of the entire oral mucous membranes and tongue glossitis, stomatitis as well as mucosal ulceration recurrent aphthous ulcers in vitamin b12 and folate deficiency have long been recognized table 1. Pdf oral manifestations of hematological disorders.
The oral manifestations and mean red blood cell rbc count, corpuscular cell volume, rbc distribution width, mentzer index, and green and king index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin b12, folic acid, and homocysteine in 75 ida patients and in 150 age and sexmatched healthy controls were measured and compared. Pale oral mucosa loss of papillae from tongue angular chelitis oral infection aphthae burning or sore tongue. Without enough iron, your body cant produce enough of a substance in red blood cells that enables. Case report a 68yearold female patient presented to the department of oral medicine with a chief complaint of mobility of the lower left teeth for 3 months. Symptoms resulting from anemia predominates the clinical picture, apart from the additional features such as glossitis, angular cheilitis, and dysphagia. Brennan mt1, sankar v, baccaglini l, pillemer sr, kingman a, nunez o, young ns, atkinson jc. They may be the direct result of disease pathology, secondary infiltrative processes, or treatmentrelated adverse effects. It is important to remember that biofilm is the etiologic agent of gingivitis and gingival bleeding is one of the main clinical signs of this inflammation. Oral manifestations of nutritional deficiencies include nonspecific signs and symptoms that involve the mucous membrane, the teeth and the periodontal tissues, salivary glands and perioral skin. Pdf backgroundpurpose iron deficiency anemia ida is the most common type of anemia. Background purpose iron deficiency anemia ida is the most common type of anemia. Pdf oral cavity is the window to the body and is often the area where systemic disease first presents itself.
Anemia is often selfinduced, and can therefore be prevented through a healthy, wellrounded diet. Oral manifestations of hypothyroidism impact factor. Jun 17, 2015 clinical features and oral manifestations of iron deficiency anemia often asymptomatic, may have nonspecific symptoms such as weakness and fatigue in severe cases may see angular cheilitis, pallor of oral tissue, and an erythematous, smooth, painful tongue 617201585. As the name implies, iron deficiency anemia is due to insufficient iron. Sue seale, dds, msd abstract congenital hypoplastic anemia is a rare disease characterized by a normochromic, normocytic anemia, a deficiency of erythroblasts in the marrow, and normal leukocyte and platelet counts.
The clinician judges the state of the vascular system of his patient by noting the condition of the peripheral capillaries as it is manifested in the color of the lips and nails and the general appearance of the skin. Clinical manifestations included melanin skin pigmentation, skin vascular and ocular anomalies. Oral manifestations of sickle cell disease article pdf available in british dental journal official journal of the british dental association. Oral manifestations of anemia in hivaids patients without. Oral manifestations of anemia in hivaids patients without arv treatment wahyu hidayat et al. Describe the metabolic and physiologic responses to anemia, with emphasis on those that give rise to the clinical findings c. Oral manifestations in congenital hypoplastic anemia. Distribution of oral manifestation of anemia no oral manifestation. Mucosal pallor, jaundice, and paresthesia may appear as the oral manifestations of hemolytic anemia. Diagnosis and management of pernicious anemia springerlink. Oral manifestations compatible with chronic graftversus. Oral manifestations in patients with aplastic anemia.
Oral symptoms and signs may include atrophic glossitis ag, generalized oral mucosal atrophy, and tenderness or burning sensation of oral mucosa. Oral manifestations of blood disorders arsalan wahid malik. This study evaluated whether ida patients had specific oral manifestations and a particular blood profile compared to normal controls. Nutrition and oral mucosal diseases danielle marie thomas, baa, ginat w. C 4, 11, 14 all adult men and postmenopausal women with iron deficiency anemia should be screened for gastrointestinal malignancy. Sickle cell anemia is a multisystem disease that can affect the oral region. Therefore, thrombocytopenia acts as a modifying agent of the. Pdf oral manifestations and blood profile in patients. The prevalence, risk factors and significance of oral manifestations in aplastic anemia have not been well characterized. A plastic anemia aa is a rare blood dyscrasia in which peripheral blood pancytopenia results from reduced or absent blood cell production in the bone marrow, and normal hematopoietic tissue in the bone marrow has been replaced by fatty marrow. A quantitative analysis of clinical manifestations, oral lesions and panoramic radiographs was performed in 33 patients.
Hemolytic anemia is a condition when there is a decreased number of erythrocyte in the circulation due to premature destruction. Request pdf oral manifestations of anaemia anaemia is a disease characterized by a decreased concentration of haemoglobin in the blood below the estimated range given by gender and age. However, 1 of the most common complications after hsct is the. It is one of the syndromes associated with iron deficiency anemia. A computerized literature search using medline was conducted for published articles on orofacial manifestations of hematological diseases, with emphasis on anemia. Comparable items are sufficiently sinus and jaw bone patterns can be identified only on radiographs. Hyperkeratotic and lichenoid lesions were the manifestations most frequent observed. Table 1 shows the prevalence rates of these and other oral manifestations in. Additional oral manifestations of lupus erythematosus may include honeycomb plaques silvery white, scarred plaques. Oral manifestations many oral manifestations are common to different type of anemia, but some may be more specific oral findings in patients with anemia usually relate to the underlying cause of the anemia. As discussed here, oral manifestations can be the presenting symptom for many systemic diseases, and thus a careful medical and social history is critical to. Pdf oral manifestations in patients with aplastic anemia. Associations between oral manifestations dental management were also comment.
This sample of patients with fanconi anemia presented a high prevalence of oral chronic graftversushost disease. Angular stomatitis painful fissures at the corners of the mouth and cheilosis dry scaling of the. Pdf oral manifestations and blood profile in patients with iron. Gaddey, md on examination, the oral cavity may exhibit manifestations of underlying systemic disease and serve as an. We report a case of diagnosis of iron deficiency anemia through oral manifestation.
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